Document Detail


Circulating soluble intercellular adhesion molecule 1 and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults Study.
MedLine Citation:
PMID:  22179741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Soluble intercellular adhesion molecule 1 (sICAM-1) is associated with endothelial dysfunction and clinical cardiovascular disease. We investigated the relationship of subclinical atherosclerosis with sICAM-1 concentration.
METHODS: sICAM-1 concentration was assayed at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) Study (black and white men and women, average age 40 years). We assessed progression of coronary artery calcification (CAC) through year 20 (n = 2378), and both carotid artery stenosis (n = 2432) and intima-media thickness (IMT) at year 20 (n = 2240).
RESULTS: Median sICAM-1 was 145.9 μg/L. Among a subgroup with advanced atherosclerotic plaque (either CAC or stenosis), IMT was 0.010 (95% CI 0.003-0.017 mm) higher per SD of sICAM-1 (44 μg/L) in a model adjusted for age, race, sex, clinic, smoking, exercise, body size, education, blood pressure, antihypertensive medication, plasma lipids, and cholesterol-lowering medication. With the same adjustment, the odds ratio (OR) for the presence of year-20 carotid artery stenosis per SD of sICAM-1 was 1.12 (95% CI 1.01-1.25, P < 0.04), whereas for occurrence of CAC progression the OR was 1.16 (1.04-1.31, P < 0.01). The associations with CAC and carotid stenosis were strongest in the top 20th of the sICAM-1 distribution.
CONCLUSIONS: sICAM-1 concentration may be an early biomarker that indicates changes in the artery wall that accompany atherosclerosis, as well as the presence of advanced plaque in the coronary and carotid arteries. This finding holds in people with low total burden of atherosclerosis, decades before the development of clinical CVD.
Authors:
Myron D Gross; Suzette J Bielinski; Jose R Suarez-Lopez; Alex P Reiner; Kent Bailey; Bharat Thyagarajan; J Jeffrey Carr; Daniel A Duprez; David R Jacobs
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-12-16
Journal Detail:
Title:  Clinical chemistry     Volume:  58     ISSN:  1530-8561     ISO Abbreviation:  Clin. Chem.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-03-15     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Atherosclerosis / blood,  diagnosis*,  pathology
Biological Markers / blood
Calcinosis / diagnosis
Carotid Intima-Media Thickness
Carotid Stenosis / blood,  diagnosis,  pathology
Coronary Artery Disease / blood,  diagnosis,  pathology
Coronary Vessels / pathology
Female
Humans
Intercellular Adhesion Molecule-1 / blood*
Male
Risk Assessment
Solubility
Young Adult
Grant Support
ID/Acronym/Agency:
1R01-HL53560-01A1/HL/NHLBI NIH HHS; HHSN268200425204C//PHS HHS; HHSN268200425205C//PHS HHS; N01 HC005187/HC/NHLBI NIH HHS; N01 HC048047/HC/NHLBI NIH HHS; N01 HC048048/HC/NHLBI NIH HHS; N01 HC048049/HC/NHLBI NIH HHS; N01 HC048050/HC/NHLBI NIH HHS; N01 HC095095/HC/NHLBI NIH HHS; N01-HC-05187/HC/NHLBI NIH HHS; N01-HC-48047/HC/NHLBI NIH HHS; N01-HC-48048/HC/NHLBI NIH HHS; N01-HC-48049/HC/NHLBI NIH HHS; N01-HC-48050/HC/NHLBI NIH HHS; N01-HC-95095/HC/NHLBI NIH HHS; N01HC05187/HL/NHLBI NIH HHS; N01HC48047/HL/NHLBI NIH HHS; N01HC48048/HL/NHLBI NIH HHS; N01HC48049/HL/NHLBI NIH HHS; R01 HL053560/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 126547-89-5/Intercellular Adhesion Molecule-1
Comments/Corrections

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