| Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left bundle branch block with preserved systolic function. | |
| | |
MedLine Citation:
|
PMID: 11399338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Deterioration of left ventricular function during follow-up was reported in some patients with syndrome X and concomitant left bundle branch block. The patients with syndrome X and left bundle branch block has been frequently presented with elevated Endothelin-1 (ET-1) level while brain natriuretic peptide (BNP) (a sensitive marker of left ventricular dysfunction) has not been measured in patients with syndrome X. METHODS: The purpose of the present study was to assess left ventricular diastolic function, levels of N-terminal Brain Natriuretic Peptide (NT-proBNP) precursor and biochemical parameters of endothelial function in patients with syndrome X complicated by left bundle branch block but preserved left ventricular systolic function (group A, n=8). The echocardiographic and neurohormonal measures in these patients were compared to those in patients with syndrome X without left bundle branch block (group B, n=13), and controls (group C, n=15). RESULTS: At rest and after exercise the serum concentration of NT-proBNP was significantly higher in group A than in the controls (at rest: 232+/-96 vs. 133+/-23 fmol/ml, P=0.03; after exercise: 313+/-96 vs. 180+/-33 fmol/ml, P=0.02). The highest concentration of endothelin-1 was also found in group A, being significantly higher than in the controls (6.81 vs. 4.52 pg/ml, P<0.05). Mitral flow abnormalities were detected in left bundle branch block patients. Accordingly, the lowest E/A ratio was in group A and it differed significantly from that in group C (0.85 vs. 1.1, P<0.05). E/A ratio inversely correlated with plasma NT-proBNP concentration in patients with left bundle branch block (r=-0.48, P=0.02). CONCLUSIONS: Elevated NT-proBNP and endothelin-1 plasma concentrations were demonstrated in patients with syndrome X complicated by left bundle branch block even when left ventricular systolic function was still preserved. In this subgroup the magnitude of left ventricular diastolic dysfunction correlated with the increase of BNP level which reflects neurohormonal activation. |
| | |
Authors:
|
D Dudek; L Rzeszutko; P Petkow Dimitrow; S Bartus; D Sorysz; M Chyrchel; T Rakowski; A Zdzienicka; I Guevara; A Dembinska-Kiec; J S Dubiel |
Related Documents
:
|
15563108 - Clinical and pathological aspects of experimental oleander (nerium oleander) toxicosis ... 47388 - Cardiac histamine-ouabain interaction: potentiation by ouabain of the arrhythmogenic ef... 1163438 - The significance of bundle branch block during acute myocardial infarction. 1644078 - Significance of ventricular late potentials in non-ischaemic dilated cardiomyopathy. 17588438 - Intermediate results after a modified yasui procedure with the lecompte maneuver. 3390648 - Ventricular noradrenaline concentrations in naïve and morphine-treated rats subjected ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of cardiology Volume: 79 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2001 Jun |
Date Detail:
|
Created Date: 2001-06-11 Completed Date: 2001-08-30 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 25-30 Citation Subset: IM |
Affiliation:
|
IInd Department of Cardiology, Jagiellonian University, Kopernika 17, 31-501, Krakow, Poland. mcdudek@cyf.kr.edu.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bundle-Branch Block
/
blood*,
physiopathology*,
ultrasonography Endothelins / blood* Female Heart Ventricles / ultrasonography Humans Male Microvascular Angina / blood*, physiopathology*, ultrasonography Middle Aged Natriuretic Peptide, Brain / blood* Protein Precursors / blood* Systole / physiology* Ventricular Function, Left / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Endothelins; 0/Protein Precursors; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Endothelin release: a marker for the severity of exercise-induced ischemia.
Next Document: Effect of beta-blockade on heart rate variability in decompensated heart failure.