Document Detail


Circulating CD14+CD16+ monocyte subsets as biomarkers of the severity of coronary artery disease in patients with stable angina pectoris.
MedLine Citation:
PMID:  22785372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Circulating monocytes can be divided into 2 subsets typically identified by the expression of CD14 and CD16. Although previous studies have shown that circulating monocytes contribute to the progression of coronary atherosclerotic lesions, the relationship between the severity of coronary artery disease (CAD) and the 2 distinct monocyte subsets has not previously been evaluated. We investigated the relationship between the monocyte subsets and the severity of CAD assessed by coronary angiography (CAG) in patients with stable angina pectoris (SAP).
METHODS AND RESULTS:  We enrolled 125 patients who underwent diagnostic CAG. Patients were divided into 3 groups: those without CAD, those with single-vessel disease (SVD), and those with multiple-vessel disease (MVD). In addition, the severity of CAD was evaluated by Gensini score. The 2 monocyte subsets (CD14(+)CD16(-) and CD14(+)CD16(+)) were measured by flow cytometry. Circulating CD14(+)CD16(+) monocytes were more frequently observed in patients with MVD than in those with SVD or without CAD. The proportion of CD14(+)CD16(+) monocytes positively correlated with Gensini score (r=0.618, P<0.001). Multivariate logistic regression analysis revealed that the proportion of CD14(+)CD16(+) monocytes was an independent contributor to MVD (odds ratio: 1.475; 95% confidence interval: 1.273-1.708, P<0.001).
CONCLUSIONS:  A preferential increase in peripheral CD14(+)CD16(+) monocytes may be closely related to the severity of CAD in patients with SAP. 
Authors:
Yuichi Ozaki; Toshio Imanishi; Akira Taruya; Hiroshi Aoki; Tomizo Masuno; Yasutsugu Shiono; Kenichi Komukai; Takashi Tanimoto; Hironori Kitabata; Takashi Akasaka
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-29
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  76     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-25     Completed Date:  2013-02-14     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2412-8     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Angina Pectoris / blood*,  complications,  radiography
Antigens, CD14 / blood*
Biological Markers
Coronary Angiography
Coronary Artery Disease / blood*,  complications,  radiography
Female
GPI-Linked Proteins / blood
Gene Expression Regulation
Humans
Male
Middle Aged
Monocytes*
Plaque, Atherosclerotic / blood,  complications,  radiography
Receptors, IgG / blood*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Antigens, CD14; 0/Biological Markers; 0/FCGR3B protein, human; 0/GPI-Linked Proteins; 0/Receptors, IgG
Comments/Corrections
Comment In:
Circ J. 2012;76(10):2331-2   [PMID:  22971906 ]

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