| Circulating Microparticles in Children with Sleep Disordered Breathing. | |
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MedLine Citation:
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PMID: 21273295 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract INTRODUCTION: Endothelial dysfunction is a common complication of pediatric obstructive sleep apnea (OSA). Circulating cell-derived microparticles (MPs) have emerged as reliable biomarkers of endothelial dysfunction and atherosclerosis. METHODS: Children underwent blood drawing the morning after a sleep study. Endothelial function was assessed with a modified hyperemic test after cuff-induced occlusion of the brachial artery. Circulating microparticles (MPs) levels in plasma including endothelial MPs, endothelial progenitor MPs, leukocyte MPs, and platelet MPs were measured by flow cytometry after staining with cell-specific antibodies. RESULTS: Endothelial MPs and endothelial progenitor MPs, leukocyte MPs, and platelet MPs levels were significantly different according to severity of OSA in children. Leukocyte CD11b+ MPs and platelet CD41a+ MPs correlated with apnea hypopnea index (AHI) (r=0.334, P<0.001 and r=0.301, P<0.001, respectively), and associations between leukocyte CD11b+ MPs and apolipoprotein B (r=0.206, p<0.05), and endothelial MPs and LDL cholesterol (r=0.240, P<0.01) emerged. In a multivariate regression model, BMI z score (β±SE; 0.045±0.020, P=0.020) and CD41a MPs to leukocyte CD45 MPs ratio (β±SE; 0.074±0.032, P=0.021) were independently associated with peak hyperemic responses. After controlling for age, gender, race, BMI z score, and apolipoprotein B, endothelial MPs, endothelial progenitor MPs, and leukocyte MPs showed independent associations with AHI. Complex significant associations emerged between endothelial function, AHI and CD41a MPs. CONCLUSIONS: Childhood OSA is associated with higher circulating MP levels that may promote cardiovascular risk. Platelet-derived MPs emerge as being significantly associated with the vascular dysfunction associated with OSA in children and could potentially account for increased risk for altered endothelial function. However, the clinical use of MPs as reliable biomarker indicators of vascular risk will have to await further studies. |
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Authors:
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Jinkwan Kim; Rakesh Bhattacharjee; Leila Kheirandish-Gozal; Karen Spruyt; David Gozal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-27 |
Journal Detail:
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Title: Chest Volume: - ISSN: 1931-3543 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, The University of Chicago, Chicago, IL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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