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Circulating Levels of Vascular Endothelial Growth Factor A and Its Soluble Receptor in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease.
MedLine Citation:
PMID:  21376261     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: Vascular endothelial growth factor A (VEGF) is a multifunctional cytokine affecting angiogenesis and vascular function. The biological activity of VEGF is modulated by its soluble receptor VEGFR-1 (sVEGFR-1). We explored the associations of VEGF and sVEGFR-1 concentrations with liver histology in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD).
METHODS: The study was comprised of 99 patients with NAFLD and 75 healthy controls. Serum VEGF and sVEGFR-1 concentrations were measured using commercially available enzyme-linked immunosorbent assays.
RESULTS: Serum VEGF levels did not differ in patients with NAFLD (1882 ± 942 pg/mL) compared with healthy controls (1985 ± 945 pg/mL, p = 0.42). However, compared with healthy subjects, levels of sVEGFR-1 were significantly lower in patients with NAFLD (1.59 ± 0.58 ng/mL vs. 1.16 ± 0.34 ng/mL, respectively, p <0.001). After allowance for potential confounders, serum sVEGFR-1 levels retained their independent significance as a predictor of liver fibrosis in patients with NAFLD (β = -0.19; t = -1.81, p <0.05).
CONCLUSIONS: Our results show that patients with biopsy-proven NAFLD have a significant reduction in serum sVEGFR-1 concentrations that predict the degree of liver fibrosis, independent of potential confounders.
Authors:
Yusuf Yilmaz; Oya Yonal; Ramazan Kurt; Yesim Ozen Alahdab; Osman Ozdogan; Cigdem Ataizi Celikel; Engin Ulukaya; Nese Imeryuz; Cem Kalayci; Erol Avsar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of medical research     Volume:  42     ISSN:  1873-5487     ISO Abbreviation:  Arch. Med. Res.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312706     Medline TA:  Arch Med Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Gastroenterology, Marmara University School of Medicine, Altunizade, Istanbul, Turkey.
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