Document Detail


Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes.
MedLine Citation:
PMID:  20955782     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Developmental exposure to estrogenic compounds can disrupt sexual differentiation and adult reproductive function in many animals including humans. Phytoestrogens (plant estrogens) in the diet comprise a significant source of estrogenic exposure to humans, particularly in infants who are fed soy-based infant formula. Animal models have been developed to test the effects of phytoestrogen exposure on the developing fetus and neonate. Here we review studies quantifying the amount of phytoestrogen exposure in human adults and infants and discuss the few available epidemiological studies that have addressed long-term consequences of developmental phytoestrogen exposure. We then describe in detail rodent models of developmental exposure to the most prevalent phytoestrogen in soy products, genistein, and the effects of this exposure on female reproductive function. These models have used various dosing strategies to mimic the phytoestrogen levels in human populations. Serum circulating levels of genistein following each of the models and their correlation to reproductive outcomes are also discussed. Taken together, the studies clearly demonstrate that environmentally relevant doses of genistein have significant negative impacts on ovarian differentiation, estrous cyclicity, and fertility in the rodent model. Additional studies of reproductive function in human populations exposed to high levels of phytoestrogens during development are warranted.
Authors:
Wendy N Jefferson; Carmen J Williams
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2010-10-15
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  31     ISSN:  1873-1708     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-07-26     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States. jeffers1@niehs.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Animals, Newborn
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Routes
Environmental Exposure
Estrous Cycle / drug effects,  physiology
Female
Fertility / drug effects*,  physiology
Genistein / adverse effects,  blood*
Humans
Infant
Infant, Newborn
Isoflavones / adverse effects
Male
Maternal Exposure / adverse effects*
Organ Size / drug effects
Ovary / drug effects,  pathology,  physiopathology
Phytoestrogens / adverse effects,  blood*
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced*
Uterus / drug effects,  pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
ZIA ES102405-04/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Isoflavones; 0/Phytoestrogens; 1POG3SCN5T/genistin; 446-72-0/Genistein
Comments/Corrections

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