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Circulating levels of clara cell protein 16 but not surfactant protein d identify and quantify lung damage in patients with multiple injuries.
MedLine Citation:
PMID:  21045740     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: : Almost 60% of all patients with severe multiple injuries sustain severe chest trauma with aggravating effect on morbidity and mortality. Diagnosis of lung contusion is performed by early posttraumatic multislice computed tomography. Because this diagnostic procedure requires time, resources, and exposure to radiation, a noninvasive approach with easy follow-up measurements is warranted.
METHODS: : Serum levels of Clara cell protein 16 (CC16) and surfactant protein D as lung-specific biomarkers were obtained on admission from 104 patients with multiple injuries using enzyme-linked immunosorbent assay technique. Patients were divided into those with severe lung injury ([LI]; n = 68) and without LI (NLI; n = 36). Nonsmoking healthy volunteers served as controls. In addition, volume of lung contusions were calculated planimetrically on serial multislice computed tomography scans obtained after admission. Factors influencing CC16 serum levels were determined in uni- and multivariate analyses, and Spearman rank coefficients were calculated for correlations.
RESULTS: : Patients with LI showed a significant (p < 0.05) elevation of median CC16 levels (10.2 ng/mL) compared with NLI patients (5.4 ng/mL) and controls (5.2 ng/mL). Serum CC16 levels correlated with the volume of lung contusions (r = 0.78, p < 0.0001) and were not influenced by overall injury severity, age, gender, or preclinical ventilation. In contrast, circulating surfactant protein D levels were not associated with the presence of LI or the extent of lung contusions.
CONCLUSIONS: : Our results advocate CC16 as a potential biomarker for LI in severely injured patients because of its high correlation with the volume of contused lung parenchyma. Therefore, this parameter may allow a specified initial treatment of patients with multiple injuries.
Sebastian Wutzler; Thomas Lehnert; Helmut Laurer; Mark Lehnert; Marco Becker; Dirk Henrich; Thomas Vogl; Ingo Marzi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  71     ISSN:  1529-8809     ISO Abbreviation:  J Trauma     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E31-6     Citation Subset:  AIM; IM    
From the Departments of Trauma, Hand, and Reconstructive Surgery (S.W., H.L., M.L., M.B., D.H., I.M.) and Radiology (T.L., T.V.), Hospital of the Johann Wolfgang, Goethe-University, Frankfurt, Germany.
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