Document Detail

Circulating IL-8 levels in heart failure patients with and without metabolic syndrome.
MedLine Citation:
PMID:  19410569     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been suggested that the metabolic syndrome (MetS) is associated with increased risk for heart failure (HF) and progression of HF. However, the underlying mechanisms are unclear. We tested whether the presence of the MetS would be associated with the increased degree of inflammatory state in HF. METHODS: Ninety-one eligible consecutive stable HF patients participated in this cross-sectional study. Anthropometric measurements were carried out and serum concentrations of lipoproteins, apolipoproteins (apoB, apoAI) and high sensitivity C-reactive protein (hsCRP) were measured. The simultaneous measurement of 17 cytokines using bioplex analysis was used. RESULT: Thirty-five subjects (39% of total, 48% of males and 31% of females) were classified as having the MetS in total HF patients. Serum concentrations of apoB (p<0.005) were significantly higher and the ratio of apoAI and apoB was significantly lower (p<0.01) in HF patients with MetS than those without MetS. Plasma levels of IL-8 (p<0.05) were significantly higher in HF patients with MetS than those without MetS. In addition, serum concentrations of hsCRP (p<0.005) were significantly higher in HF patients with MetS compared to those without MetS. CONCLUSIONS: The MetS in HF is associated with increased degree of inflammation, which provides information regarding the relationship between inflammation and HF with MetS.
Min-Jeong Shin; Kyung Hye Lee; Ji Hyung Chung; Yoo Kyoung Park; Mi Kyung Choi; Jaewon Oh; Ji Won Choi; Sang-Hak Lee; Namsik Chung; Seok-Min Kang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-03
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  405     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-42     Citation Subset:  IM    
Department of Food and Nutrition, Korea University, Seoul, Republic of Korea.
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MeSH Terms
Blood Glucose / metabolism
C-Reactive Protein / metabolism
Heart Failure / blood*,  complications*
Interleukin-8 / blood*
Lipoproteins / blood
Metabolic Syndrome X / blood*,  complications*
Middle Aged
Reg. No./Substance:
0/Blood Glucose; 0/Interleukin-8; 0/Lipoproteins; 9007-41-4/C-Reactive Protein

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