| Circulating IL-21 levels increase during early simian-human immunodeficiency virus infection in macaques. | |
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MedLine Citation:
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PMID: 23224786 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The cytokine interleukin-21 (IL-21) regulates viral pathogenesis in individuals infected with human and simian immunodeficiency viruses. However, because the time of initial infection with HIV in humans is rarely known, the dynamics of IL-21 production during the first weeks have not been adequately explored. In the present study, we used rhesus macaques to model the first stages of infection. Twenty-two rhesus macaques were infected rectally with simian-human immunodeficiency virus (SHIV)-1157ipd3N4, and for 12 weeks, replication of the virus, the numbers of CD4+ and CD8+ T cells, and the levels of plasma IL-21 were monitored. Our study demonstrated that plasma levels of IL-21 increased during the early phase of SHIV infection when compared with the values observed before inoculation. We conclude that IL-21 has a likely role in the immunopathogenesis of HIV/SIV/SHIV. |
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Authors:
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Chang-Cheng Zhao; Jing Xue; Zhe Cong; Xi-Qiang Gao; Wei-Lun Zhang; Ting Chen; Fang-Xin Wu; Jing Xiong; Bin Ju; Aihua Su; Qiang Wei; Chuan Qin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-8 |
Journal Detail:
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Title: Archives of virology Volume: - ISSN: 1432-8798 ISO Abbreviation: Arch. Virol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506870 Medline TA: Arch Virol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences and Comparative Medical Center, No.5 Panjiayuan Nanli, Chaoyang Dist, 100021, Beijing, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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