Document Detail


Circulating IL-21 levels increase during early simian-human immunodeficiency virus infection in macaques.
MedLine Citation:
PMID:  23224786     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The cytokine interleukin-21 (IL-21) regulates viral pathogenesis in individuals infected with human and simian immunodeficiency viruses. However, because the time of initial infection with HIV in humans is rarely known, the dynamics of IL-21 production during the first weeks have not been adequately explored. In the present study, we used rhesus macaques to model the first stages of infection. Twenty-two rhesus macaques were infected rectally with simian-human immunodeficiency virus (SHIV)-1157ipd3N4, and for 12 weeks, replication of the virus, the numbers of CD4+ and CD8+ T cells, and the levels of plasma IL-21 were monitored. Our study demonstrated that plasma levels of IL-21 increased during the early phase of SHIV infection when compared with the values observed before inoculation. We conclude that IL-21 has a likely role in the immunopathogenesis of HIV/SIV/SHIV.
Authors:
Chang-Cheng Zhao; Jing Xue; Zhe Cong; Xi-Qiang Gao; Wei-Lun Zhang; Ting Chen; Fang-Xin Wu; Jing Xiong; Bin Ju; Aihua Su; Qiang Wei; Chuan Qin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-8
Journal Detail:
Title:  Archives of virology     Volume:  -     ISSN:  1432-8798     ISO Abbreviation:  Arch. Virol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506870     Medline TA:  Arch Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences and Comparative Medical Center, No.5 Panjiayuan Nanli, Chaoyang Dist, 100021, Beijing, People's Republic of China.
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