Document Detail


Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome.
MedLine Citation:
PMID:  22850287     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Factor VII activating protease (FSAP) is a circulating serine protease strongly expressed in unstable plaques and may serve as a marker of plaque destabilization. The aim of this study was to examine the relation between plasma concentrations of FSAP and clinical instability and outcome in coronary artery disease (CAD). Methods and Results: Circulating FSAP concentration and activity, as well as FSAP mRNA expression in monocytes, were measured in 231 sequential patients who underwent coronary angiography because of stable angina pectoris (n=50), unstable angina pectoris (n=43), or acute myocardial infarction (n=87). FSAP activity, but not FSAP antigen concentration, was elevated in patients with CAD compared with a control group. Elevated FSAP activity (≥1.035 plasma equivalent units [PEU]/ml) indicated a significantly increased risk of death or non-fatal myocardial infarction during 1 year of follow-up as compared with patients with low activity of FSAP (odds ratio 1.895 [95% confidence interval 1.093-3.283]; P=0.023). Furthermore, there were no significant changes in the FSAP expression in monocytes from CAD and control subjects in the basal state but there were differences after stimulation with proinflammatory factors. Conclusions: Plasma FSAP activity was significantly increased in patients with acute coronary syndrome and may be involved in the pathogenesis of these conditions. High levels of FSAP activity were predictive of adverse events during follow-up, suggesting its potential role in risk stratification and clinical management of CAD patients.
Authors:
Mariana S Parahuleva; Hans Hölschermann; Daniel Zandt; Jörn Pons-Kühnemann; Behnoush Parviz; Ralf Weiskirchen; Anne Staubitz; Harald Tillmanns; Ali Erdogan; Sandip M Kanse
Related Documents :
21118837 - Cerebral thromboembolism in a patient awaiting surgery for left ventricular diverticulum.
22178057 - Osteoprotegerin/rank/rankl axis and atrial remodeling in mitral valvular patients with ...
22216087 - A crucial role of activin a-mediated growth hormone suppression in mouse and human hear...
22244567 - Late remote ischemic preconditioning in children undergoing cardiopulmonary bypass: a r...
8423657 - The appropriateness of use of percutaneous transluminal coronary angioplasty in new yor...
6851017 - Quantitation of regional cardiac function by two-dimensional echocardiography. i. patte...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-28
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  -     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Internal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on th...
Next Document:  Noninvasive ventilation in pulmonary edema complicating acute myocardial infarction.