| Circulating Dickkopf-1 and osteoprotegerin in patients with early and longstanding rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 20819596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Rheumatoid arthritis (RA) is characterized by inflammation of the synovial membrane, leading to invasion of synovial tissue into the adjacent cartilage matrix with degradation of articular cartilage and bone as a consequence. Dickkopf-1 (DKK-1) and osteoprotegerin (OPG) have been demonstrated to be key molecules involved in bone erosion and bone remodeling. The aim of this study was to explore the potential role of DKK-1 and OPG in different stage of RA. METHODS: The protein levels of DKK-1 and OPG were detected by ELISA. The serum samples were collected from 300 patients with RA and 60 healthy controls. Of which, 150 RA patients were defined as early RA (disease duration < or = 1 year), and other 150 RA patients were defined as longlasting RA (disease duration > or = 5 years). At the time of serum sampling, various clinical and laboratory parameters were assessed. The correlations of DKK-1 or OPG and clinical/laboratory parameters were analyzed. RESULTS: The serum level of DKK-1 was elevated in patients with longstanding RA compared with healthy controls, while no significant difference was observed between the two groups in the level of OPG. In contrast, in early RA patients, the circulating OPG was elevated, while there was no significant difference between the two groups in expression of DKK-1. The serum DKK-1 was correlated with Sharp score and DAS28 in longstanding RA patients. In early RA, age was the only parameter that was significantly related to serum OPG. CONCLUSIONS: There was a cross-talk between DKK-1 and OPG, which involved in bone destruction in RA. In different stage of RA, DKK-1 and OPG may play different roles in the pathogenesis of RA. |
| | |
Authors:
|
Yan-ying Liu; Li Long; Shi-yao Wang; Jian-ping Guo; Hua Ye; Liu-fu Cui; Guo-hua Yuan; Zhan-guo Li |
Related Documents
:
|
7612046 - Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera ... 3797956 - An inhibitor of complement-mediated prevention of immune precipitation in rheumatoid ar... 7966066 - Osteocalcin in patients with rheumatoid arthritis. a one-year followup study. 21521926 - Clinicopathological features of primary aldosteronism associated with subclinical cushi... 10782546 - Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in re... 11092696 - Prevalence of thyroid peroxidase, thyroglobulin and thyrotropin receptor antibodies in ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chinese medical journal Volume: 123 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-09-07 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
|
Languages: eng Pagination: 1407-12 Citation Subset: IM |
Affiliation:
|
Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arthritis, Rheumatoid / blood* Enzyme-Linked Immunosorbent Assay Female Humans Intercellular Signaling Peptides and Proteins / blood* Male Middle Aged Osteoprotegerin / blood* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/DKK1 protein, human; 0/Intercellular Signaling Peptides and Proteins; 0/Osteoprotegerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical features of multiple myeloma invasion of the central nervous system in Chinese patients.
Next Document: Hepatic blood inflow occlusion with/without hemihepatic artery control versus the Pringle maneuver i...