Document Detail


Circulating D-dimers as a marker of disease activity in pulmonary sarcoidosis.
MedLine Citation:
PMID:  16022144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: The search is on to find an easily measurable marker of disease activity in sarcoidosis. The present study was carried out to evaluate the utility of plasma D-dimer as a marker of disease activity in sarcoidosis. METHODS: Thirty newly diagnosed cases of sarcoidosis with clinical indications for treatment and an equal number of matched healthy controls were studied for the presence of D-dimers (DD) in the plasma before starting treatment with oral prednisolone and after clinical remission. Semi-quantitative estimations of DD were done using the latex agglutination slide test method (Commercial Kit - Diagnostica Stago, France) as per the manufacturer's recommendations. RESULTS: The mean age of cases and controls were 45.43 +/- 8.5 (range 34-60) and 46.16 +/- 8.07 (range 32-61) years, respectively. Of the 30 patients, nine (30%) were DD positive at baseline. The DD positive patients presented more often with dyspnoea, had radiological stage III (7 out of 9) disease and abnormal spirometry compared to patients with no detectable DD in their plasma. Of the 16 patients re-evaluated after clinical remission, eight (50%) were D-dimer positive. Two of the five patients initially DD positive had become negative and five additional patients who were negative at baseline had become positive. CONCLUSIONS: Plasma D-dimers, which were positive in 30% of untreated patients of sarcoidosis, indicate patients with significant pulmonary parenchymal involvement; but have no correlation with clinical disease remission.
Authors:
Dheeraj Gupta; Sanjeev Gupta; T Balamugesh; Ashutosh N Aggarwal; Reena Das
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Indian journal of chest diseases & allied sciences     Volume:  47     ISSN:  0377-9343     ISO Abbreviation:  Indian J Chest Dis Allied Sci     Publication Date:    2005 Jul-Sep
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612044     Medline TA:  Indian J Chest Dis Allied Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Affiliation:
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dgupta@glide.net.in
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood*
Case-Control Studies
Disease Progression
Female
Fibrin Fibrinogen Degradation Products / analysis*
Humans
Male
Middle Aged
Prognosis
Sarcoidosis, Pulmonary / pathology*
Sensitivity and Specificity
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

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