Document Detail


Circulating cytokines reflect mucosal inflammatory status in patients with Crohn's disease.
MedLine Citation:
PMID:  19834804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is a great need for a simple activity assessment tool that can reliably predict activity in patients with Crohn's disease (CD). AIM: To investigate the relationship between serum cytokines and endoscopic activity of CD using Crohn's Disease Endoscopic Index of Severity (CDEIS) as a gold standard. METHODS: We prospectively evaluated 32 firmly established CD patients using ileocolonoscopy, CDEIS score, and Crohn's Disease Activity Index (CDAI) score. Blood samples for cytokine analysis were obtained 1 day prior to procedure. RESULTS: The correlation between CDEIS and CDAI was moderate (r = 0.43; P = 0.01); however, the correlation between CDEIS and inflammatory cytokines was excellent, with the highest coefficients for tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) (r = 0.96 and r = 0.96, respectively; P < 0.001). CDEIS and anti-inflammatory cytokines were correlated nonlinearly (power function). We identified two separate models for predicting CDEIS value, based on the best performing pro-inflammatory [CDEIS = 0.445 x (IL-6) - 5,143] and anti-inflammatory [CDEIS = 27.478 x (IL-10)(-0.71)] cytokines. Both IL-6 and IL-10 models had high adjusted R(2) values (0.916 and 0.954, respectively). IL-6 had excellent diagnostic accuracy for detecting patients with CDEIS >7 (active disease), with area under the receiver operating characteristic (ROC) curve of 1.0 [95% confidence interval (CI) = 0.89-1.0; P < 0.001]. CONCLUSION: Serum cytokine levels are excellent predictors of endoscopic activity in patients with CD.
Authors:
Farid Ljuca; Adnan Gegic; Nermin N Salkic; Nada Pavlovic-Calic
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Publication Detail:
Type:  Journal Article     Date:  2009-10-16
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-29     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2316-26     Citation Subset:  AIM; IM    
Affiliation:
Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Crohn Disease / blood*
Cytokines / blood*,  metabolism*
Female
Humans
Intestinal Mucosa / metabolism,  pathology*
Male
Middle Aged
Young Adult
Chemical
Reg. No./Substance:
0/Cytokines

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