Document Detail


Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment.
MedLine Citation:
PMID:  17684516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maintenance of uninterrupted cerebral circulation is critical for neural homeostasis. The level of circulating CD34-positive (CD34(+)) cells has been suggested as an index of cerebrovascular health, although its relationship with cognitive function has not yet been defined. In a group of individuals with cognitive impairment, the level of circulating CD34(+) cells was quantified and correlated with clinical diagnoses. Compared with normal subjects, a significant decrease in circulating CD34(+) cells was observed in patients with vascular-type cognitive impairment, although no significant change was observed in patients with Alzheimer's-type cognitive impairment who had no evidence of cerebral ischemia. The level of cognitive impairment was inversely correlated with numbers of circulating CD34(+) cells in patients with vascular-type cognitive impairment, but not Alzheimer's type. We propose that the level of circulating CD34(+) cells provides a marker of vascular risk associated with cognitive impairment, and that differences in the pathobiology of Alzheimer's- and vascular-type cognitive impairment may be mirrored in levels of circulating CD34(+) cells in these patient populations.
Authors:
Akihiko Taguchi; Tomohiro Matsuyama; Takayuki Nakagomi; Yoko Shimizu; Ryuzo Fukunaga; Yoshiaki Tatsumi; Hiroo Yoshikawa; Akie Kikuchi-Taura; Toshihiro Soma; Hiroshi Moriwaki; Kazuyuki Nagatsuka; David M Stern; Hiroaki Naritomi
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-08-08
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  28     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  445-9     Citation Subset:  IM    
Affiliation:
Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan. taguchi@ri.ncvc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Antigens, CD34*
Biological Markers / blood
Case-Control Studies
Cognition Disorders / diagnosis
Dementia, Vascular / diagnosis*
Female
Humans
Leukocyte Count
Leukocytes / pathology*
Male
Risk
Severity of Illness Index*
Chemical
Reg. No./Substance:
0/Antigens, CD34; 0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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