| Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction. | |
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MedLine Citation:
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PMID: 18698330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence points to a role for circulating endothelial progenitors, including populations of CD34-positive (CD34(+)) cells present in peripheral blood, in vascular homeostasis and neovascularization. In this report, circulating CD34(+) cells in individuals with a history of cerebral infarction were correlated with changes in neurologic function over a period of 1 year. Patients with decreased levels of CD34(+) cells displayed significant worsening in neurologic function, evaluated by the Barthel Index and Clinical Dementia Rating. These results support the hypothesis that levels of circulating CD34(+) cells have prognostic value for neural function, consistent with their potential role in maintaining cerebral circulation. |
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Authors:
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Akihiko Taguchi; Nami Nakagomi; Tomohiro Matsuyama; Akie Kikuchi-Taura; Hiroo Yoshikawa; Yukiko Kasahara; Haruka Hirose; Hiroshi Moriwaki; Takayuki Nakagomi; Toshihiro Soma; David M Stern; Hiroaki Naritomi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-13 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 29 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-31 Completed Date: 2009-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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Department of Cerebrovascular Disease, National Cardiovascular Center, Osaka, Japan. taguchi@ri.ncvc.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD34 / metabolism* Cell Movement* Central Nervous System / cytology*, metabolism* Cerebral Infarction / metabolism*, pathology* Female Follow-Up Studies Humans Male Prognosis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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