| Circulating Antibodies to IDO/THO Pathway Metabolites in Alzheimer's Disease. | |
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MedLine Citation:
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PMID: 20721333 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol from the latter. Other compounds, such as kynurenic acid, serotonin, and melatonin are produced via the same pathways. An improved ELISA method identified circulating antibodies directed against these compounds, linked to proteins, as previously described for other chronic diseases. This describes how only the A isotype of circulating immunoglobulins recognized a pattern of conjugated tryptophan metabolites in the sera of Alzheimer patients. These data indirectly confirmed the involvement of tryptophan derivatives in the pathogenic processes of Alzheimer's disease. Further studies are required to evaluate the relevance of these antibody patterns in monitoring this disease. |
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Authors:
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S Duleu; A Mangas; F Sevin; B Veyret; A Bessede; M Geffard |
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Publication Detail:
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Type: Journal Article Date: 2010-03-15 |
Journal Detail:
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Title: International journal of Alzheimer's disease Volume: 2010 ISSN: 2090-0252 ISO Abbreviation: Int J Alzheimers Dis Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525141 Medline TA: Int J Alzheimers Dis Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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IDRPHT, 33400 Talence, France. |
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