Document Detail


Circularized chromosome with a large palindromic structure in Streptomyces griseus mutants.
MedLine Citation:
PMID:  15150216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Streptomyces linear chromosomes display various types of rearrangements after telomere deletion, including circularization, arm replacement, and amplification. We analyzed the new chromosomal deletion mutants Streptomyces griseus 301-22-L and 301-22-M. In these mutants, chromosomal arm replacement resulted in long terminal inverted repeats (TIRs) at both ends; different sizes were deleted again and recombined inside the TIRs, resulting in a circular chromosome with an extremely large palindrome. Short palindromic sequences were found in parent strain 2247, and these sequences might have played a role in the formation of this unique structure. Dynamic structural changes of Streptomyces linear chromosomes shown by this and previous studies revealed extraordinary strategies of members of this genus to keep a functional chromosome, even if it is linear or circular.
Authors:
Tetsuya Uchida; Naoto Ishihara; Hiroyuki Zenitani; Keiichiro Hiratsu; Haruyasu Kinashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bacteriology     Volume:  186     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-19     Completed Date:  2004-06-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3313-20     Citation Subset:  IM    
Affiliation:
Department of Molecular Biotechnology, Hiroshima University, Higashi-Hiroshima 739-8530, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Chromosome Deletion
Chromosomes, Bacterial*
Gene Amplification
Molecular Sequence Data
Mutation
Streptomyces griseus / genetics*
Terminal Repeat Sequences
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