| Circular reasoning: microRNAs and cell-cycle control. | |
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MedLine Citation:
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PMID: 18774719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MicroRNAs (miRNAs) have attracted considerable attention because of their important roles in development, normal physiology, and disease states including cancer. Recent studies have identified specific miRNAs that regulate the cell cycle and have documented that the loss or gain of miRNA-mediated cell-cycle control contributes to malignancy. miRNAs regulate classic cell-cycle control pathways by directly targeting proteins such as E2F transcription factors, cyclin-dependent kinases (Cdks), cyclins and Cdk inhibitors. Moreover, from recent findings, it has been suggested that miRNAs themselves might be subject to cell-cycle dependent regulation. Together, these observations indicate that the reciprocal control of RNA silencing and the metazoan cell cycle impacts cellular behavior and disease. |
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Authors:
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Raghu R Chivukula; Joshua T Mendell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-09-05 |
Journal Detail:
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Title: Trends in biochemical sciences Volume: 33 ISSN: 0968-0004 ISO Abbreviation: Trends Biochem. Sci. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-02-19 Revised Date: 2010-12-17 |
Medline Journal Info:
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Nlm Unique ID: 7610674 Medline TA: Trends Biochem Sci Country: England |
Other Details:
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Languages: eng Pagination: 474-81 Citation Subset: IM |
Affiliation:
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McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Cell Cycle / genetics* Cell Division Cyclins / physiology Humans MicroRNAs / genetics* Neoplasms / pathology, physiopathology Transcription Factors / genetics, physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA120185/CA/NCI NIH HHS; R01 CA120185-01A2/CA/NCI NIH HHS; R01 CA120185-02/CA/NCI NIH HHS; R01 CA120185-03/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyclins; 0/MicroRNAs; 0/Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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