Document Detail


Circuitry underlying spectrotemporal integration in the auditory midbrain.
MedLine Citation:
PMID:  21976527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combination sensitivity in central auditory neurons is a form of spectrotemporal integration in which excitatory responses to sounds at one frequency are facilitated by sounds within a distinctly different frequency band. Combination-sensitive neurons respond selectively to acoustic elements of sonar echoes or social vocalizations. In mustached bats, this response property originates in high-frequency representations of the inferior colliculus (IC) and depends on low and high frequency-tuned glycinergic inputs. To identify the source of these inputs, we combined glycine immunohistochemistry with retrograde tract tracing. Tracers were deposited at high-frequency (>56 kHz), combination-sensitive recording sites in IC. Most glycine-immunopositive, retrogradely labeled cells were in ipsilateral ventral and intermediate nuclei of the lateral lemniscus (VNLL and INLL), with some double labeling in ipsilateral lateral and medial superior olivary nuclei (LSO and MSO). Generally, double-labeled cells were in expected high-frequency tonotopic areas, but some VNLL and INLL labeling appeared to be in low-frequency representations. To test whether these nuclei provide low frequency-tuned input to the high-frequency IC, we combined retrograde tracing from IC combination-sensitive sites with anterograde tracing from low frequency-tuned sites in the anteroventral cochlear nucleus (AVCN). Only VNLL and INLL contained retrogradely labeled cells near (≤50 μm) anterogradely labeled boutons. These cells likely receive excitatory low-frequency input from AVCN. Results suggest that combination-sensitive facilitation arises through convergence of high-frequency glycinergic inputs from VNLL, INLL, or MSO and low-frequency glycinergic inputs from VNLL or INLL. This work establishes an anatomical basis for spectrotemporal integration in the auditory midbrain and a functional role for monaural nuclei of the lateral lemniscus.
Authors:
Asuman Yavuzoglu; Brett R Schofield; Jeffrey J Wenstrup
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-06     Completed Date:  2011-11-18     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14424-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods*
Animals
Auditory Pathways / physiology*
Chiroptera
Female
Male
Mesencephalon / physiology*
Nerve Net / physiology*
Time Factors
Grant Support
ID/Acronym/Agency:
R01 DC000937/DC/NIDCD NIH HHS; R01 DC000937-19S1/DC/NIDCD NIH HHS; R01 DC000937-20/DC/NIDCD NIH HHS; R01 DC004391/DC/NIDCD NIH HHS; R01 DC004391-11A1/DC/NIDCD NIH HHS; R01 DC00937-19S1/DC/NIDCD NIH HHS; R01 DC00937-20/DC/NIDCD NIH HHS; R01 DC04391/DC/NIDCD NIH HHS
Comments/Corrections

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