Document Detail


Circuit modeling of the electrical impedance: I. Neuromuscular disease.
MedLine Citation:
PMID:  23353926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multifrequency electrical impedance myography (MFEIM) in the 3-300 kHz range was applied to 68 subjects representing 19 different neuromuscular diseases, and the impedances analyzed using the 5-element circuit model. Depending on severity, the 'cellular' parameters r(2), r(3), 1/c(1) and 1/c(2) were found to be as much as 10- to 20-fold larger than for normal subjects (taking age and girth into account), but in almost every case the extracellular fluid parameter r(1) was at most only marginally affected. Strong correlations are found between r(2) and 1/c(1,) but in the case of ALS that breaks down when c(1) (representing the muscle fiber membrane capacitance) falls below half the normal value. Also, c(2) (tentatively associated with intracellular organelle membranes) was found to be the most sensitive to disease progress in ALS, about three times more so than the 50 kHz phase, already suggested for use in clinical drug testing. We conclude that following parameters obtained using the combined MFEIM/5-element circuit analysis scheme offer a reliable, non-invasive and objective way of characterizing muscle in neuromuscular disease or during clinical drug testing.
Authors:
C A Shiffman; S B Rutkove
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-28
Journal Detail:
Title:  Physiological measurement     Volume:  34     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-08-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Computer Simulation
Conductometry / methods*
Diagnosis, Computer-Assisted / methods*
Electric Impedance / diagnostic use
Humans
Male
Middle Aged
Models, Neurological*
Muscle, Skeletal / physiopathology*
Neuromuscular Diseases / diagnosis*,  physiopathology*
Reproducibility of Results
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 NS042037/NS/NINDS NIH HHS; R01-NS04203/NS/NINDS NIH HHS
Comments/Corrections

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