Document Detail


Circuit modeling of the electrical impedance: II. Normal subjects and system reproducibility.
MedLine Citation:
PMID:  23354000     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Part I of this series showed that the five-element circuit model accurately mimics impedances measured using multi-frequency electrical impedance myography (MFEIM), focusing on changes brought on by disease. This paper addresses two requirements which must be met if the method is to qualify for clinical use. First, the extracted parameters must be reproducible over long time periods such as those involved in the treatment of muscular disease, and second, differences amongst normal subjects should be attributable to known differences in the properties of healthy muscle. It applies the method to five muscle groups in 62 healthy subjects, closely following the procedure used earlier for the diseased subjects. Test-retest comparisons show that parameters are reproducible at levels from 6 to 16% (depending on the parameter) over time spans of up to 267 days, levels far below the changes occurring in serious disease. Also, variations with age, gender and muscle location are found to be consistent with established expectations for healthy muscle tissue. We conclude that the combination of MFEIM measurements and five-element circuit analysis genuinely reflects properties of muscle and is reliable enough to recommend its use in following neuromuscular disease.
Authors:
C A Shiffman; S B Rutkove
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-28
Journal Detail:
Title:  Physiological measurement     Volume:  34     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-08-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Computer Simulation
Conductometry / methods*
Diagnosis, Computer-Assisted / methods*
Electric Impedance / diagnostic use
Humans
Male
Middle Aged
Models, Neurological*
Muscle, Skeletal / physiology*
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 NS042037/NS/NINDS NIH HHS; R01-NS04203/NS/NINDS NIH HHS
Comments/Corrections

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