| Circannual variation in the onset and relapse of steroid-sensitive nephrotic syndrome. | |
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MedLine Citation:
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PMID: 15719252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic nephrotic syndrome is the most common form of nephrotic syndrome in children, but little is known about the etiology of the disease. To obtain new insights into the etiology of the disease, we studied circannual patterns of initial episodes and relapses of steroid-sensitive nephrotic syndrome (SSNS). From 1986 to 2003, there were 45 children with SSNS in our hospital, and they experienced 43 relapses during that period. Initial episodes of SSNS were found to show significant circannual variation with an autumn peak both by Roger's test and Freedman's test, and the circannual pattern was more obvious in patients with high serum IgE levels. Chronological evaluation by means of Fourier analysis showed a clear circannual pattern. In contrast, relapses of SSNS showed circannual variation with a spring peak, which was a result of a high frequency of relapses after upper respiratory infections in January. These results suggest that circannual variation in initial episodes of SSNS might be associated with allergic predisposition, whereas circannual variation in relapses might be associated with preceding upper respiratory infections. |
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Authors:
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Shin-ichi Toyabe; Makiko Nakamizo; Makoto Uchiyama; Kouhei Akazawa |
Publication Detail:
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Type: Journal Article Date: 2005-02-18 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 20 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-04 Completed Date: 2005-06-30 Revised Date: 2006-04-19 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 470-3 Citation Subset: IM |
Affiliation:
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Department of Medical Informatics, Niigata University Medical and Dental Hospital, Asahimachi-dori 1-754, 951-8520 Niigata, Japan. toyabe@med.niigata-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Animals Child Child, Preschool Dust Female Fourier Analysis Humans Hypersensitivity / complications Immunoglobulin E / blood Infant Male Mites / immunology Nephrotic Syndrome / complications, drug therapy*, immunology, physiopathology* Recurrence Respiratory Tract Infections / complications Retrospective Studies Seasons* Steroids / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Dust; 0/Steroids; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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