Document Detail

Circadian variations in the superoxide production, enzyme release and neutrophil aggregation in patients with rheumatoid arthritis and controls.
MedLine Citation:
PMID:  1849434     Owner:  NLM     Status:  MEDLINE    
Patients with rheumatoid arthritis (RA) experience fluctuations of symptoms throughout the day. These could be due to mechanical changes or modification of the inflammatory mechanisms. In the present paper we studied fluctuations of superoxide production (O2), enzyme release (beta-glucuronidase and lysozyme) and neutrophil aggregation in the peripheral blood of eight healthy volunteers and eight patients with RA. Although enzyme release was greater in patients with RA, no significant difference was found throughout the day, neither in control nor in patients. Similar results were obtained when studying neutrophil aggregation. On the contrary, the superoxide production, determined at 8:00, 14:00, and 20:00 h, was 6.3 +/- 0.5, 4.40 +/- 0.4 and 6.26 +/- 0.3, respectively, in patients with RA and 6.65 +/- 0.7, 4.7 +/- 0.7 and 7.27 +/- 0.4 in the controls. The values obtained at 14:00 h were significantly lower (alpha = 0.01). There were no differences in the curve form between patients and controls.
M A Muniain; M D Rodríguez; A Romero; R Mata; C Vargas; A Naranjo
Related Documents :
20952464 - Increased prevalence of metabolic syndrome associated with rheumatoid arthritis in pati...
17602844 - The accuracy of magnetic resonance imaging of the hands and feet in the diagnosis of ea...
2484314 - Susceptibility epitope on hla-dr beta chain for rheumatoid arthritis and the effect of ...
15287534 - Respiratory symptoms in rheumatoid arthritis: relation between high resolution ct findi...
16580754 - One of the most frequent vascular diseases in northeastern of turkey: thromboangiitis o...
3943694 - Esophageal motor function in patients with muscular dystrophy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  30     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-15     Completed Date:  1991-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  138-40     Citation Subset:  AIM; IM    
Department of Internal Medicine, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arthritis, Rheumatoid / enzymology,  metabolism*
Cell Aggregation
Circadian Rhythm*
Neutrophils / enzymology,  metabolism,  physiology*
Reference Values
Superoxides / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Risk of tuberculosis in patients with HIV-I and HIV-II infections in Abidjan, Ivory Coast.
Next Document:  Chronic selective blockade of mu opioid receptors produces analgesia and augmentation of the effects...