Document Detail

Circadian variations of human flexion reflex.
MedLine Citation:
PMID:  2944057     Owner:  NLM     Status:  MEDLINE    
We investigated 8 healthy male volunteers, evaluating RII and RIII thresholds every 6 h starting from noon, for a 24-h period. Both reflex responses exhibited a circadian rhythmicity: the lowest values were found in the early morning (9.1 +/- 3.0 and 13.1 +/- 4.4 mA, respectively), while the highest values were observed at midnight (13.1 +/- 3.5 and 18.5 +/- 5.3 mA). Also mean cosinor analysis indicated the existence of a significant rhythm with acrophase at 20:12 for RII and 22:29 for RIII. In 4 subjects, beta-endorphin plasma (beta-EP) level was tested during the day. No correlation was observed between circadian changes of beta-EP and RIII threshold. Other factors are likely to be involved in the circadian variation of nociceptive flexion reflex in man.
G Sandrini; E Alfonsi; G Bono; F Facchinetti; L Montalbetti; G Nappi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pain     Volume:  25     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-09-26     Completed Date:  1986-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  403-10     Citation Subset:  IM    
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MeSH Terms
Circadian Rhythm*
Endorphins / blood
Muscle Contraction
Muscles / innervation
Nociceptors / physiopathology
Pain / physiopathology*
Reaction Time / physiology
Reflex / physiology*
Sensory Thresholds
Sural Nerve / physiopathology
Touch / physiology
Reg. No./Substance:
0/Endorphins; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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