Document Detail

Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium.
MedLine Citation:
PMID:  697058     Owner:  NLM     Status:  MEDLINE    
Circadian rhythms in DNA synthesis are described for the tongue epithelium, five different regions of the alimentary canal (gut)--esophagus, stomach, duodenum, jejunum and rectum--and bone marrow in a group of BDF1 male mice. A circadian rhythm is also described for the mitotic index in the corneal epithelium in the same mice. The data document for the first time in the same animals the dramatic variation in cell division encountered from one region of the gut to another. This variation is seen in the amplitudes of the rhythms as well as in the over-all 24-hour means. On the contrary, the phasings of the rhythms in the different regions of the gut are remarkably similar. In this study, where the mice were standardized to 12 hours of light (0600-1800) alternating with 12 hours of darkness, the peak of the DNA-synthesis rhythm occurred around the time of transition from dark to light, and the trough around the time of transition from light to dark. The implications of these findings, and those of others, to the study of cell kinetics and to cancer chemotherapy are discussed.
L E Scheving; E R Burns; J E Pauly; T H Tsai
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Anatomical record     Volume:  191     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-11-22     Completed Date:  1978-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
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MeSH Terms
Bone Marrow Cells*
Cell Division
Circadian Rhythm*
Cornea / cytology*
DNA / biosynthesis*
Digestive System / cytology*
Epithelial Cells
Esophagus / cytology*
Reg. No./Substance:

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