| Circadian variation in blood pressure: dipper or nondipper. | |
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MedLine Citation:
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PMID: 12147922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Awareness of an increased incidence of cardiovascular events shortly after awakening has heightened interest in the chronopathology of cardiovascular diseases. Blood pressure varies according to cycles characterized by a reduction during sleep and an increase on awakening. The surge in blood pressure coincides with the circadian nature of various endocrine and hematologic parameters that also have a putative role in triggering the onset of cardiovascular events. The nighttime decrease is absent or blunted in some hypertensive patients (termed nondippers), an effect associated with increased morbidity. Drugs can influence the effect of these circadian patterns. Research efforts are focused on clarifying an underlying pathophysiologic process that could be modified by pharmacologic or other means. Long-acting angiotensin II receptor blockers have an effect on blood pressure over 24 hours due to their long half-life, but could also limit the morning surge in blood pressure through an effect on the renin-angiotensin-aldosterone and noradrenergic systems. |
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Authors:
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Pierre Larochelle |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 4 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-07-30 Completed Date: 2005-09-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 3-8 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Le Jacq Communications, Inc. |
Affiliation:
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Département de Pharmacologie, Centre de Recherche, Centre Hospitalier de l'Université de Montréal, Quèbec, Canada. pierre.larochelle@umontreal.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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physiology* Blood Pressure Monitoring, Ambulatory Cardiovascular Diseases / physiopathology Circadian Rhythm / physiology* Humans Myocardial Contraction / physiology Renin-Angiotensin System / physiology Sleep / physiology Vascular Resistance / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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