| Circadian variation in baroreflex sensitivity evaluated by beat-to-beat hemodynamic change in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 7473046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms underlying the higher incidence of cardiovascular events in the morning were investigated by studying the circadian variation in hemodynamics and baroreflex sensitivity (BRS) in 20 untreated inpatients with essential hypertension. Direct blood pressure (BP) and heart rate (HR) were recorded using telemetry. Cardiac output (CO) was measured by the dye dilution method. Beat-to-beat stroke volume (SV) and total peripheral vascular resistance (TPR) were obtained using the pulse contour method. The coefficient of regression between HR and systolic BP (SBP) change (delta HR/delta SBP = Ahr) was calculated for in 5 consecutive heart beats during which BP decreased spontaneously and linearly (r > 0.9). Similarly, the delta SV/delta SBP (= Asv) and delta TPR/delta SBP (= Atpr) were also measured, and the negative values of these coefficients (-Ahr, -Asv and -Atpr) were calculated. Comparisons between morning (6-11 a.m.) and evening (4-9 p.m.) values showed no significant difference in mean BP (122 vs 127 mmHg) and HR (72 vs 73 bpm). However, CO (3.7 vs 4.2 l/min), -Ahr (0.28 vs 0.43 bpm/mmHg) and -Asv (-1.5 vs 1.4 ml/mmHg) were lower in the morning than in the evening (p < 0.01). In contrast, TPR (40 vs 34 mmHg/l/min) and -Atpr (1.2 vs -1.4 min/l) were higher in the morning than in the evening (p < 0.01). These findings suggest that lower -Ahr and -Asv and higher TPR and -Atpr may cause stress to the cardiovascular system in the morning in patients with essential hypertension. |
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Authors:
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Y Kawano; O Tochikubo; E Miyajima; M Ishii |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiology Volume: 26 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-12-13 Completed Date: 1995-12-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Urafune Hospital Affiliated to Yokohama City University School of Medicine. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autonomic Nervous System / physiopathology Baroreflex / physiology* Circadian Rhythm* Female Hemodynamics* Humans Hypertension / physiopathology* Male Middle Aged |
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