Document Detail


Circadian topology of metabolism.
MedLine Citation:
PMID:  23151577     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level.
Authors:
Joseph Bass
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  491     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  348-56     Citation Subset:  IM    
Affiliation:
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA. j-bass@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P01AG011412/AG/NIA NIH HHS; P60 DK020595/DK/NIDDK NIH HHS; R01DK090625/DK/NIDDK NIH HHS; R01HL097817/HL/NHLBI NIH HHS

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