| Circadian time-qualified tolerance intervals for ambulatory blood pressure monitoring in the diagnosis of hypertension. | |
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MedLine Citation:
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PMID: 15129829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The large-amplitude circadian pattern in blood pressure of healthy subjects of both genders suggests that the constant threshold currently used to diagnose hypertension should be replaced by a time-specified reference limit reflecting the mostly predictable blood pressure variability during the 24 h. Accordingly, we derived circadian time-specified reference standards for blood pressure as a function of gender. We studied 743 normotensive Caucasian volunteers (400 men and 343 women), 45.7 +/- 16.5 (mean +/- SD) years of age. Blood pressure was measured by ambulatory monitoring at 20-min intervals during the day and at 30-min intervals at night for 48 consecutive hours. Data from each blood pressure series were synchronized according to the rest-activity cycle of each individual in order to avoid differences among subjects in actual times of daily activity. Data were then used to compute 90% circadian tolerance intervals for each gender separately. The method, derived on the basis of bootstrap techniques, does not need to assume normality or symmetry in the data and, therefore, it is highly appropriate to describe the circadian pattern of blood pressure variability. Results reflect expected changes in the tolerance limits as a function of gender and circadian sampling time, as well as upper blood pressure limits below the thresholds currently used for diagnosing hypertension, especially for women. The use of these time-dependent tolerance limits for the computation of a hyperbaric index as a measure of blood pressure excess has already been shown to provide a reproducible and high-sensitivity test for the diagnosis of hypertension, which can also be used to evaluate treatment efficacy. |
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Authors:
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Ramón C Hermida; José R Fernández; Diana E Ayala; Artemio Mojón; Ignacio Alonso; Carlos Calvo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chronobiology international Volume: 21 ISSN: 0742-0528 ISO Abbreviation: Chronobiol. Int. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-05-07 Completed Date: 2004-11-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8501362 Medline TA: Chronobiol Int Country: United States |
Other Details:
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Languages: eng Pagination: 147-60 Citation Subset: IM |
Affiliation:
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Bioengineering Laboratory, University of Vigo, Campus Universitario, Vigo, Spain. rhermida@tsc.uvigo.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Blood Pressure Monitoring, Ambulatory* Circadian Rhythm / physiology* Female Heart Rate / physiology Humans Hypertension / diagnosis*, physiopathology* Male Middle Aged |
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