Document Detail


Circadian system of mice integrates brief light stimuli.
MedLine Citation:
PMID:  9688706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Light is the primary sensory stimulus that synchronizes or entrains the internal circadian rhythms of animals to the solar day. In mammals photic entrainment of the circadian pacemaker residing in the suprachiasmatic nuclei is due to the fact that light at certain times of day can phase shift the pacemaker. In this study we show that the circadian system of mice can integrate extremely brief, repeated photic stimuli to produce large phase shifts. A train of 2-ms light pulses delivered as one pulse every 5 or 60 s, with a total light duration of 120 ms, can cause phase shifts of several hours that endure for weeks. Single 2-ms pulses of light were ineffective. Thus these data reveal a property of the mammalian circadian clock: it can integrate and store latent sensory information in such a way that a series of extremely brief photic stimuli, each too small to cause a phase shift individually, together can cause a large and long-lasting change in behavior.
Authors:
A N Van Den Pol; V Cao; H C Heller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  275     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-16     Completed Date:  1998-09-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R654-7     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm / physiology*
Light
Male
Mammals
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Motor Activity / physiology*
Photic Stimulation
Time Factors
Grant Support
ID/Acronym/Agency:
NS-10174/NS/NINDS NIH HHS; NS-31573/NS/NINDS NIH HHS; NS-34887/NS/NINDS NIH HHS

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