Document Detail


Circadian rhythms in Mexican blind cavefish Astyanax mexicanus in the lab and in the field.
MedLine Citation:
PMID:  24225650     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Biological clocks have evolved as an adaptation to life on a rhythmic planet, synchronising physiological processes to the environmental light-dark cycle. Here we examine circadian clock function in Mexican blind cavefish Astyanax mexicanus and its surface counterpart. In the lab, adult surface fish show robust circadian rhythms in per1, which are retained in cave populations, but with substantial alterations. These changes may be due to increased levels of light-inducible genes in cavefish, including clock repressor per2. From a molecular standpoint, cavefish appear as if they experience 'constant light' rather than perpetual darkness. Micos River samples show similar per1 oscillations to those in the lab. However, data from Chica Cave shows complete repression of clock function, while expression of several light-responsive genes is raised, including DNA repair genes. We propose that altered expression of light-inducible genes provides a selective advantage to cavefish at the expense of a damped circadian oscillator.
Authors:
Andrew Beale; Christophe Guibal; T Katherine Tamai; Linda Klotz; Sophie Cowen; Elodie Peyric; Víctor H Reynoso; Yoshiyuki Yamamoto; David Whitmore
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature communications     Volume:  4     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  2769     Citation Subset:  IM    
Affiliation:
1] Centre for Cell and Molecular Dynamics, Department of Cell and Developmental Biology, University College London, 21 University Street, London WC1E 6DE, UK [2].
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