Document Detail

Circadian rhythms of heart rate and blood pressure after heart transplantation.
MedLine Citation:
PMID:  1386753     Owner:  NLM     Status:  MEDLINE    
Blood pressure and heart rate were recorded over 24-hour periods on 39 occasions in 20 subjects 5 to 72 weeks after heart transplantation. All patients were receiving cyclosporine, azathioprine, and prednisolone. In 38 of the 39 records the mean nighttime heart rate was lower than the mean daytime rate, with a peak difference of 20.1 +/- 1.8 beats/min. Blood pressure responses were, however, of two patterns. In 15 of the 39 recordings (approximately 50% of patients) the mean nighttime systolic pressure was higher than the mean daytime systolic pressure; in the remainder the converse was observed. The pattern was generally consistent on repeated recordings from the same patient and was not related to time since transplantation, renal function, or other therapy. Echocardiographic/Doppler studies were available at the time of 31 of these recordings. No differences in left ventricular diameters, systolic function, or transmitral filling patterns were present between patients whose blood pressure was higher or lower at night. Left ventricular posterior wall thickness and the ratio between wall thickness and ventricular diameter at end diastole were greater in the group showing nighttime pressure falls. Blood pressure responses after heart transplantation show the presence of nighttime "dippers" and "nondippers." At least early after transplantation, however, nondipper status is not preferentially associated with the development of left ventricular hypertrophy. The mechanisms accounting for the different circadian blood pressure responses in heart transplant recipients are not known.
A M Dart; J K Yeoh; G L Jennings; J D Cameron; D S Esmore
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  11     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1992 Jul-Aug
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  784-92     Citation Subset:  IM    
Alfred and Baker Medical Unit, Alfred Hospital, Prahran, Victoria, Australia.
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MeSH Terms
Blood Pressure / physiology*
Cardiomegaly / epidemiology
Circadian Rhythm / physiology*
Echocardiography, Doppler
Heart Rate / physiology*
Heart Transplantation / physiology*
Hypertension / epidemiology
Middle Aged
Monitoring, Physiologic
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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