Document Detail

Circadian rhythms of blood pressure, heart rate, and locomotor activity in spontaneously hypertensive rats as measured with radio-telemetry.
MedLine Citation:
PMID:  8190809     Owner:  NLM     Status:  MEDLINE    
Circadian rhythms of blood pressure, heart rate, and locomotor activity were measured with implanted radio-telemetry transmitters in conscious, unrestrained spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). During the light period (0600 to 1800 h) systolic, diastolic, and mean blood pressure, heart rate, and locomotor activity were lower than during the dark period (1800 to 0600 h). During the first and the last hour of the dark period, all parameters showed a relative peak when compared to values during the rest of the night. The pattern of circadian changes in blood pressure, heart rate, or behavior was essentially similar in SHR and WKY. Blood pressure values were always higher in SHR than in WKY, but there was no general strain difference in heart rate or locomotor activity values. The administration of hydralazine in the drinking water resulted in a significant decrease in blood pressure in SHR and WKY, and a suppression of the difference between light-phase values and dark-phase values. By contrast, heart rate showed an overall increase in both strains, whereas locomotor activity was largely unaffected. These data show the validity of telemetry as a means of measuring circadian rhythms of blood pressure, heart rate, and behavior in freely moving rats. Apart from their characteristic hypertension, SHR show few differences with WKY with respect to other parameters, such as circadian rhythmicity, baseline heart rate values, or behavior. Some of the previously published differences between SHR and WKY may have been influenced by the stress of the experimental procedures used.
M van den Buuse
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  55     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-17     Completed Date:  1994-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  783-7     Citation Subset:  IM    
Marion Merrell Dow Research Institute, Strasbourg, France.
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MeSH Terms
Blood Pressure / drug effects,  physiology*
Circadian Rhythm / drug effects,  physiology*
Heart Rate / drug effects,  physiology*
Hydralazine / pharmacology
Motor Activity / drug effects,  physiology*
Radio Waves
Rats, Inbred SHR
Rats, Inbred WKY
Signal Processing, Computer-Assisted / instrumentation
Species Specificity
Telemetry / instrumentation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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