Document Detail

Circadian rhythms and autoregulatory transcription loops--going round in circles?
MedLine Citation:
PMID:  9027318     Owner:  NLM     Status:  MEDLINE    
Recent advances in the molecular analysis of biological timing have appeared to bring us closer to an answer to the 'big question', namely, 'What is the timing mechanism that enables an organism to measure the circadian (around 24 h) period?'. In this minireview, we consider the validity of the fashionable concept that autoregulatory feedback loops, centered on transcription, form the basis of the clock, and we offer a fresh view of recent progress as it relates to mammalian systems.
D A Carter; D Murphy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  124     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-16     Completed Date:  1997-04-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Physiology Unit, School of Molecular and Medical Biosciences, Cardiff University of Wales, UK.
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MeSH Terms
Biological Clocks / genetics
Circadian Rhythm / genetics*
Homeostasis / physiology*
Transcription, Genetic / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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