Document Detail

Circadian rhythms of RNA, DNA and protein in the rat thyroid, adrenal and testis in chronic pesticide exposure. III. Effects of the insecticides (dichlorvos and trichlorphon).
MedLine Citation:
PMID:  6196799     Owner:  NLM     Status:  MEDLINE    
Chronic exposure of the rats to Trichlorphon (10 ppm/day, over a time span of 90 days) leads to marked changes in the time structure of the thyroid and the adrenal, e.g. the loss of the circadian rhythms as a group phenomenon in thyroid DNA and protein and adrenal RNA content, phase alterations in thyroid RNA and adrenal DNA rhythms, marked decrease in amplitude of the adrenal DNA and protein rhythms. Ninety days of exposure to Dichlorvos (5 ppm/day) leads to phase alterations, without a change in the time-qualified mean (mesor), of the circadian rhythms in DNA, RNA and protein content and marked decrease in amplitude of the DNA rhythm, in the thyroid and the adrenal. In the testis, there is no alterations of the rhythms studied. The phase alterations encountered in this study are different in extent and also in direction, between and within the organs, indicating an external and internal desynchronization of metabolic and cell proliferative functions. The variability of the acrophases obtained by the separate analysis of each of the three days of study may suggest free-running rhythms.
G Y Nicolau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologie     Volume:  20     ISSN:  1011-6206     ISO Abbreviation:  Physiologie     Publication Date:    1983 Apr-Jun
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7510964     Medline TA:  Physiologie     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  93-101     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / metabolism*
Circadian Rhythm
DNA / metabolism*
Dichlorvos / pharmacology*
Pesticides / pharmacology*
Proteins / metabolism*
RNA / metabolism*
Rats, Inbred Strains
Testis / metabolism*
Thyroid Gland / metabolism*
Trichlorfon / pharmacology*
Reg. No./Substance:
0/Pesticides; 0/Proteins; 52-68-6/Trichlorfon; 62-73-7/Dichlorvos; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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