| Circadian rhythms of RNA, DNA and protein in the rat thyroid, adrenal and testis in chronic pesticide exposure. II. Effects of the herbicides Aminotriazole and Alachlor. | |
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MedLine Citation:
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PMID: 6191379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety days of exposure to Aminotriazole (500 ppm/day) leads to changes of the time structure in the rat adrenal and thyroid. The circadian rhythm in adrenal DNA content is not demonstrable in the treated animals as a group phenomenon. There is a phase advance of over five hours (+76 degrees) in the circadian rhythm in adrenal RNA and a phase delay of about nine hours (-136 degrees) in the rhythm in adrenal protein. There is an increase of the mesors (rhythm adjusted mean) and a decrease in the amplitudes of the circadian rhythms in thyroid DNA and RNA content without detectable phase alteraton and a decrease in thyroid protein mesor with a slight but statistically significant phase delay (-25 degrees). The circadian rhythms of the three parameters studied in the testis were not changed by Aminotriazole exposure. Ninety days of exposure to Alachlor (50 ppm/day) had only a minor effect on the testicular rhythms studied. The isolated decrease in thyroid RNA amplitude and the disappearance of the circadian rhythm in adrenal protein content, as a group phenomenon, were the only rhythm alterations found. A chronotoxicological approach may be of importance for the selection to relatively innocuous compounds to be used in agriculture and for the early recognition of undesirable effects in man and animals. |
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Authors:
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G Y Nicolau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrinologie Volume: 21 ISSN: 0253-1801 ISO Abbreviation: Endocrinologie Publication Date: 1983 Apr-Jun |
Date Detail:
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Created Date: 1983-08-26 Completed Date: 1983-08-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7509386 Medline TA: Endocrinologie Country: ROMANIA |
Other Details:
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Languages: eng Pagination: 105-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetamides
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toxicity* Adrenal Glands / analysis, drug effects* Amitrole / toxicity* Animals Circadian Rhythm / drug effects* DNA / analysis* Herbicides / toxicity* Male Proteins / analysis* RNA / analysis* Rats Rats, Inbred Strains Testis / analysis, drug effects* Thyroid Gland / analysis, drug effects* Triazoles / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Herbicides; 0/Proteins; 0/Triazoles; 15972-60-8/alachlor; 61-82-5/Amitrole; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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