Document Detail


Circadian rhythm of natriuresis is disturbed in nondipper type of essential hypertension.
MedLine Citation:
PMID:  9915264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the circadian rhythm of urinary sodium excretion and the effects of sodium restriction on rhythm in both dipper and nondipper types of essential hypertension. Patients (n = 26) with essential hypertension were maintained on relatively high- (10 to 12 g/d of sodium chloride) and low-sodium (1 to 3 g/d) diets for 1 week each. On the last day of each diet, 24-hour blood pressures (BPs) were measured every 30 minutes noninvasively with an automatic device, and on the last 3 days, urinary samples were collected for both daytime (7:00 AM to 9:30 PM) and nighttime (9:30 PM to 7:00 AM). Eight patients were classified as dippers based on a more than 10% reduction in mean arterial pressure (MAP) from daytime to nighttime on a high-sodium diet, and 18 patients were classified as nondippers. A nocturnal decrease in urinary sodium excretion rate (U(Na)V) on the high-sodium diet was observed in dippers (from 7.5 +/- 2.1 during the day to 5.3 +/- 2.5 mmol/h at night; P < 0.0001), but not in nondippers (6.7 +/- 2.1 v 7.6 +/- 2.3 mmol/h; not significant). In nondippers, the night-day ratio of sodium excretion was significantly reduced from 1.2 +/- 0.4 to 0.8 +/- 0.3 (P < 0.003) by sodium restriction; at the same time, the night-day ratio of MAP was reduced from 0.98 +/- 0.04 to 0.93 +/- 0.05 (P < 0.05). In dippers, the night-day ratios of MAP and U(Na)V were not affected by sodium restriction, and both ratios remained constant at less than 1. Before sodium restriction, the night-day ratio of sodium excretion correlated with that of MAP (r = 0.78; P < 0.0001), whereas there was no significant correlation (r = -0.05) after sodium restriction. These findings showed that the circadian rhythm of renal sodium excretion differed between the two types of essential hypertension. The enhanced nocturnal natriuresis and diminished nocturnal BP fall on a high-sodium diet, recognized in nondippers, were both normalized by sodium restriction, resulting in circadian rhythms with nocturnal dips in U(Na)V and BP.
Authors:
T Fujii; T Uzu; M Nishimura; M Takeji; S Kuroda; S Nakamura; T Inenaga; G Kimura
Related Documents :
7552044 - The effect of dietary protein levels on the responses of the taste nerve to sodium chlo...
7696444 - Review article: practical management of the short bowel.
16890144 - Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin ii.
9353164 - Progression of glomerulosclerosis, renal hypertrophy, and an increased expression of fi...
9725824 - Gender differences in leptin levels during puberty are related to the subcutaneous fat ...
25273604 - Challenges with effective nutrient supplementation for amphibians: a review of cricket ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  33     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Affiliation:
Division of Nephrology, National Cardiovascular Center, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analysis of Variance
Blood Pressure / physiology
Chi-Square Distribution
Circadian Rhythm / physiology*
Diet, Sodium-Restricted
Female
Humans
Hypertension / physiopathology*,  urine
Kidney / physiopathology
Male
Middle Aged
Natriuresis / physiology*
Sodium / urine
Sodium, Dietary / administration & dosage
Chemical
Reg. No./Substance:
0/Sodium, Dietary; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early immunologic and nonimmunologic predictors of arterial hypertension after renal transplantation...
Next Document:  Evaluating patients with renal failure for renal artery stenosis with gadolinium-enhanced magnetic r...