| Circadian rhythm of lymphocytes and their glucocorticoid receptors in HIV-infected homosexual men. | |
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MedLine Citation:
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PMID: 8229657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glucocorticoids (Gc) are known to modulate protein synthesis by immune cells through binding to a specific receptor (GcR). We outlined the circadian rhythm of plasma cortisol, ACTH, of the peripheral blood mononuclear cells (PBMC isolated by Ficoll-Hypaque technique), and of their subsets CD4, CD8 in 14 asymptomatic HIV+ homosexual men and in nine controls. We also estimated the GcR of the PBMC at 0700 and at 2300 hours, near the peak and nadir of the cortisol rhythm. In the HIV+ subjects, the PBMC circadian rhythm is abolished, an observation that confirms previous reports; in more than half of these patients, the GcR dissociation constant is larger than that of the controls. The circadian rhythms of plasma cortisol and ACTH levels do not differ from those of the controls. These changes may impair the function of the hypothalamic pituitary-adrenal axis in the HIV-infected subject. |
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Authors:
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A H Vagnucci; A Winkelstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes Volume: 6 ISSN: 0894-9255 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-26 Completed Date: 1993-11-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8812597 Medline TA: J Acquir Immune Defic Syndr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1238-47 Citation Subset: IM; X |
Affiliation:
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Department of Medicine, Montefiore University Hospital, Pittsburg, Pennsylvania 15213. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood Adult Circadian Rhythm* Fourier Analysis HIV Infections / immunology* Homosexuality Humans Hydrocortisone / blood Leukocyte Count Lymphocytes / physiology* Male Middle Aged Receptors, Glucocorticoid / analysis, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Glucocorticoid; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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