Document Detail


Circadian rhythm and desensitization in chemosensory event-related potentials in response to odorous and painful stimuli.
MedLine Citation:
PMID:  14570168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Olfactory (H2S) and trigeminal (CO2) event-related potentials (ERPs) were studied with respect to circadian rhythm and desensitization. ERPs, perceived odor and pain intensity, oral temperature, blood pressure, heart rate, nasal volume, and sleepiness were assessed four times at 04:00, 08:00, 12:00, 16:00, 20:00, and 24:00 hr in five young men. For each of these 24 sessions per participant, H2S and CO2 were each presented in 15 series of five stimuli with a 5-s ISI within and 30-s ISI between series. ERP amplitudes, but not latencies, followed a circadian rhythm (largest at 16:00 and smallest at 04:00) similar to oral temperature and opposite to sleepiness. Amplitudes decreased (most pronounced at 16:00 and 20:00) and latencies increased with repeated stimulation, suggesting desensitization, in accordance with odor and pain intensity. These findings imply that circadian rhythm and desensitization should be considered in chemosensory ERP studies.
Authors:
Steven Nordin; Jörn Lötsch; Claire Murphy; Thomas Hummel; Gerd Kobal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychophysiology     Volume:  40     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-10-22     Completed Date:  2003-11-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-9     Citation Subset:  IM    
Affiliation:
Department of Psychology, Umeå University, Umeå, Sweden. steven.nordin@psy.umu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Circadian Rhythm / physiology*
Cross-Over Studies
Evoked Potentials / physiology
Humans
Male
Odors*
Pain / physiopathology*
Sleep Stages / physiology
Smell / physiology*
Stimulation, Chemical
Grant Support
ID/Acronym/Agency:
DC00032/DC/NIDCD NIH HHS; DC02064/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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