Document Detail

Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol.
MedLine Citation:
PMID:  25368979     Owner:  NLM     Status:  Publisher    
Context: The endocannabinoid (eCB) system is involved in the regulation of food intake and of peripheral metabolism. While the cross-talk between energy metabolism and the circadian system is well documented, little is known about a potential circadian modulation of human eCB activity. Objective: To define the 24-hour profile of circulating levels of the most abundant endogenous ligand of the CB1 receptor, 2-arachidonoylglycerol (2-AG), in healthy young non-obese adults studied under controlled bedtime, dietary, and activity conditions. Methods: Fourteen subjects participated in this 4-day laboratory study with fixed light-dark cycles, standardized meals and bedtimes. Sleep was recorded each night. On the third day, blood sampling at 15- to 30-min intervals began at 21:30 and continued for 24 hours. Cortisol, leptin, and ghrelin were assayed on all samples, while levels of 2-AG and of its structural analog 2-oleoylglycerol (2-OG) were measured at 60-min intervals. Results: All participants exhibited a large circadian variation of 2-AG serum concentrations with a nadir around mid-sleep, coincident with the middle of the overnight fast. Levels of 2-AG increased continually across the morning, peaking in the early to midafternoon. Peak values represented, on average, a nearly threefold increase above nocturnal nadir levels. Concentrations of 2-OG followed a similar pattern, although with a shorter morning increase and lower amplitude. Conclusions: The findings demonstrate that activity of the eCB system is profoundly modulated by circadian rhythmicity and suggest that its impact on the regulation of food intake is suppressed during sleep and maximal during early to midafternoon.
Ec Hanlon; E Tasali; R Leproult; Kl Stuhr; E Doncheck; H de Wit; Cj Hillard; E Van Cauter
Related Documents :
25342149 - Hypothetical link between infertility and genetically modified food.
2819029 - A comparison of the digestion and reduction in particle size of lucerne hay (medicago s...
7361419 - A review of some animal diseases encountered at meat inspections in england and wales, ...
15737429 - Risk factors for tick attachment to smallholder dairy cattle in tanzania.
7198149 - The seasonal incidence of the major nematode genera recovered from sheep, cattle, impal...
2741309 - Photosensitization of cattle in montana: is descurainia pinnata the culprit?
12779489 - Food chain chaos due to junction-fold point.
21366579 - Food partitioning and diet temporal variation in two coexisting sparids, pagellus eryth...
19124299 - Larvivorous potential of the guppy, poecilia reticulata, in anopheline mosquito control...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-4
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-4     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  jc20143455     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dietary protein intake affects amino acid and acylcarnitine metabolism in infants aged 6 months.
Next Document:  Role of nanocrystalline silver dressings in the management of toxic epidermal necrolysis (TEN) and T...