Document Detail

Circadian rhythm of cellular proliferation in the human rectal mucosa.
MedLine Citation:
PMID:  2065918     Owner:  NLM     Status:  MEDLINE    
Circadian rhythms of DNA synthesis and cellular proliferation in the gastrointestinal mucosa have been well documented in animal models. This investigation was designed to determine whether similar rhythms could be demonstrated in the human rectal epithelium: 24 studies were performed in 16 healthy men under fasting (n = 14) and fed (n = 10) conditions. Rectal mucosal biopsy specimens were obtained through a proctoscope every 2 or 3 hours for a 24-hour span. Ex vivo measurements of tritiated thymidine incorporation into DNA were made on the mucosal samples. Feeding and time of day were each found to have an effect on the rate of thymidine incorporation into the DNA of rectal mucosal cells. Both fasted and fed subjects showed significant circadian rhythms in thymidine incorporation, which peaked at about 7 AM. Fasting lowered the overall mean thymidine uptake without altering the rhythm. Thymidine uptake generally reflects the amount of DNA synthesis in the sampled tissue. Therefore, these data may be important in the design of cancer chemotherapeutic regimens that use drugs specifically active during DNA synthesis.
K N Buchi; J G Moore; W J Hrushesky; R B Sothern; N H Rubin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  101     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-08-15     Completed Date:  1991-08-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  410-5     Citation Subset:  AIM; IM    
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.
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MeSH Terms
Analysis of Variance
Cell Division / physiology
Circadian Rhythm / physiology*
DNA / biosynthesis
Intestinal Mucosa / cytology*
Rectum / cytology*,  pathology
Grant Support
R01-31635-06//PHS HHS
Reg. No./Substance:

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