Document Detail

Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease.
MedLine Citation:
PMID:  18207455     Owner:  NLM     Status:  MEDLINE    
The symptoms of restless legs syndrome (RLS) have a circadian pattern and central nervous system dopamine has been implicated in the pathogenesis of the condition. We sought to characterize circadian variation in dopamine and related compounds in human cerebro-spinal fluid (CSF). CSF was continuously withdrawn for 22 h from an implanted lumbar intradural catheter and sampled from three patients with RLS, three patients with Parkinson's disease (PD) and three healthy volunteers. Patients had moderate disease severity and took no medications. We assayed CSF dopamine (DA), homovanillic acid (HVA), dihydroxy-phenylacetic acid (DOPAC) and 5-hydroxyindole acetic acid (5-HIAA) from samples every 30 min by reversed-phase HPLC coupled with electrochemical detection. We also measured CSF levels of hypocretin-1 every hour by RIA. The procedure was well-tolerated. One patient ended the study early due to lumbar radicular pain and was not included in the analysis. There were no changes in CSF cell counts or protein levels from the first to the last samples. There was no difference in any of the compounds between groups, so we fit 24-h cosines to examine if the entire group had significant phase consistency. There was a peak for dopamine at 10 a.m. (p<0.025) and for HVA at 2 p.m. (p<0.01), but no evidence of a significant 24-h rhythm for DOPAC, 5-HIAA, the HVA/5-HIAA ratio, or hypocretin-1. These results demonstrate a circadian rhythm for CSF dopamine and HVA concentrations in humans, with higher levels in the daytime than at nighttime. This circadian variation could underlie the symptoms of RLS and sleep-related variation in motor function in PD.
J Steven Poceta; Loren Parsons; Scott Engelland; Daniel F Kripke
Related Documents :
22163495 - A low cost device for monitoring the urine output of critical care patients.
19174795 - Elevated human beta-defensin-2 levels indicate an activation of the innate immune syste...
23920625 - Engineering natural language processing solutions for structured information from clini...
24650675 - Lifting the 'violence veil': examining working conditions in long-term care facilities ...
25243745 - Carer assessment: continuing tensions and dilemmas for social care practice.
15024335 - Risk adjusting rehabilitation outcomes: an overview of methodologic issues.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-01-22
Journal Detail:
Title:  Sleep medicine     Volume:  10     ISSN:  1389-9457     ISO Abbreviation:  Sleep Med.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-30     Revised Date:  2009-04-28    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Scripps Clinic Division of Neurology and Scripps Clinic Sleep Center, The Scripps Research Institute, Molecular and Integrative Neurosciences Department, La Jolla, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid
Biogenic Monoamines / cerebrospinal fluid*
Chromatography, High Pressure Liquid
Circadian Rhythm*
Dopamine / cerebrospinal fluid
Feasibility Studies
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Intracellular Signaling Peptides and Proteins / cerebrospinal fluid*
Middle Aged
Neuropeptides / cerebrospinal fluid*
Parkinson Disease / cerebrospinal fluid*,  physiopathology
Pilot Projects
Restless Legs Syndrome / cerebrospinal fluid*,  physiopathology
Grant Support
Reg. No./Substance:
0/Biogenic Monoamines; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid
Comment In:
Sleep Med. 2009 Feb;10(2):271; author reply 272   [PMID:  19013101 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Obstructive sleep apnea has little impact on quality of life in the elderly.
Next Document:  Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome.