Document Detail


Circadian regulation of olfaction and an evolutionarily conserved, nontranscriptional marker in Caenorhabditis elegans.
MedLine Citation:
PMID:  23185015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circadian clocks provide a temporal structure to processes from gene expression to behavior in organisms from all phyla. Most clocks are synchronized to the environment by alternations of light and dark. However, many organisms experience only muted daily environmental cycles due to their lightless spatial niches (e.g., caves or soil). This has led to speculation that they may dispense with the daily clock. However, recent reports contradict this notion, showing various behavioral and molecular rhythms in Caenorhabditis elegans and in blind cave fish. Based on the ecology of nematodes, we applied low-amplitude temperature cycles to synchronize populations of animals through development. This entrainment regime reveals rhythms on multiple levels: in olfactory cued behavior, in RNA and protein abundance, and in the oxidation state of a broadly conserved peroxiredoxin protein. Our work links the nematode clock with that of other clock model systems; it also emphasizes the importance of daily rhythms in sensory functions that are likely to impact on organism fitness and population structure.
Authors:
Maria Olmedo; John S O'Neill; Rachel S Edgar; Utham K Valekunja; Akhilesh B Reddy; Martha Merrow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-26
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  2013-02-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20479-84     Citation Subset:  IM    
Affiliation:
Department of Molecular Chronobiology, Faculty of Mathematics and Natural Science, University of Groningen, 9474 AG Groningen, The Netherlands. maria.olmedo@med-uni.muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Caenorhabditis elegans / genetics*,  physiology*
Caenorhabditis elegans Proteins / genetics,  physiology
Circadian Clocks / genetics*,  physiology*
Circadian Rhythm / genetics,  physiology
Conserved Sequence
Evolution, Molecular
G-Protein-Coupled Receptor Kinases / genetics,  physiology
Genes, Helminth
Genetic Markers
Models, Genetic
Molecular Sequence Data
Peroxiredoxin III / genetics,  physiology
Peroxiredoxins / genetics,  physiology
RNA, Helminth / genetics,  metabolism
RNA, Messenger / genetics,  metabolism
Sequence Homology, Amino Acid
Smell / genetics*,  physiology*
Temperature
Transcription Factors / genetics,  physiology
Grant Support
ID/Acronym/Agency:
083643/Z/07/Z//Wellcome Trust
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Genetic Markers; 0/LIN-42 protein, C elegans; 0/RNA, Helminth; 0/RNA, Messenger; 0/Transcription Factors; EC 1.11.1.15/PRDX-2 protein, C elegans; EC 1.11.1.15/Peroxiredoxin III; EC 1.11.1.15/Peroxiredoxins; EC 2.7.11.16/G-Protein-Coupled Receptor Kinases; EC 2.7.11.16/GRK-2 protein, C elegans
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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