Document Detail

Circadian profiles in the embryonic chick heart: L-type voltage-gated calcium channels and signaling pathways.
MedLine Citation:
PMID:  20969517     Owner:  NLM     Status:  MEDLINE    
Circadian clocks exist in the heart tissue and modulate multiple physiological events, from cardiac metabolism to contractile function and expression of circadian oscillator and metabolic-related genes. Ample evidence has demonstrated that there are endogenous circadian oscillators in adult mammalian cardiomyocytes. However, mammalian embryos cannot be entrained independently to light-dark (LD) cycles in vivo without any maternal influence, but circadian genes are well expressed and able to oscillate in embryonic stages. The authors took advantage of using chick embryos that are independent of maternal influences to investigate whether embryonic hearts could be entrained under LD cycles in ovo. The authors found circadian regulation of L-type voltage-gated calcium channels (L-VGCCs), the ion channels responsible for the production of cardiac muscle contraction in embryonic chick hearts. The mRNA levels and protein expression of VGCCα1C and VGCCα1D are under circadian control, and the average L-VGCC current density is significantly larger when cardiomyocytes are recorded during the night than day. The phosphorylation states of several kinases involved in insulin signaling and cardiac metabolism, including extracellular signal-regulated kinase (Erk), stress-activated protein kinase (p38), protein kinase B (Akt), and glycogen synthase kinase-3β (GSK-3β), are also under circadian control. Both Erk and p38 have been implicated in regulating cardiac contractility and in the development of various pathological states, such as cardiac hypertrophy and heart failure. Even though both Erk and phosphoinositide 3-kinase (PI3K)-Akt signaling pathways participate in complex cellular processes regarding physiological or pathological states of cardiomyocytes, the circadian oscillators in the heart regulate these pathways independently, and both pathways contribute to the circadian regulation of L-VGCCs.
Michael L Ko; Liheng Shi; Kirill Grushin; Fikru Nigussie; Gladys Y-P Ko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chronobiology international     Volume:  27     ISSN:  1525-6073     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-02-25     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1673-96     Citation Subset:  IM    
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MeSH Terms
Actins / genetics
Biological Clocks
Calcium Channels, L-Type / genetics,  physiology*
Chick Embryo / physiology*
Circadian Rhythm* / physiology
Gene Expression Regulation
Heart / embryology,  physiology*
MAP Kinase Kinase Kinases / metabolism
Muscle, Smooth, Vascular / physiology
Myocardium / enzymology
Myocytes, Cardiac / physiology
Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
p38 Mitogen-Activated Protein Kinases / metabolism
Grant Support
Reg. No./Substance:
0/Actins; 0/Calcium Channels, L-Type; EC Mitogen-Activated Protein Kinases; EC Kinase Kinase Kinases

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