| Circadian phase difference of leptin in android versus gynoid obesity. | |
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MedLine Citation:
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PMID: 15350697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures. |
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Authors:
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Federico Perfetto; Roberto Tarquini; Germaine Cornélissen; Giorgio Mello; Alessio Tempestini; Paola Gaudiano; Francesco Mancuso; Franz Halberg |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Peptides Volume: 25 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-07 Completed Date: 2005-02-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 1297-306 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Facoltà di Medicina e Chirurgia, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy. perfetto@unifi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Circadian Rhythm* Female Humans Hydrocortisone / blood Insulin / blood Leptin / blood* Middle Aged Obesity / classification, physiopathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 11061-68-0/Insulin; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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