Document Detail

Circadian phase difference of leptin in android versus gynoid obesity.
MedLine Citation:
PMID:  15350697     Owner:  NLM     Status:  MEDLINE    
A circadian rhythm in serum leptin, measured every 4 h for 24 h, characterizes normal-weight women (N = 14), and women with gynoid (N = 17) or android (N = 26) obesity, peaking around midnight (P < 0.05), but differing by about 3 h between android and gynoid women (P < 0.01). Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0.001) and a smaller relative circadian amplitude (P < 0.05). Gynoid obesity is associated with a larger circadian amplitude of cortisol (P < 0.05), whereas android obesity is associated with a larger circadian amplitude and a higher MESOR of insulin (P < 0.05). Understanding putative mechanisms underlying different body fat distribution may lead to improved chronotherapeutic measures.
Federico Perfetto; Roberto Tarquini; Germaine Cornélissen; Giorgio Mello; Alessio Tempestini; Paola Gaudiano; Francesco Mancuso; Franz Halberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Peptides     Volume:  25     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2005-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1297-306     Citation Subset:  IM    
Department of Internal Medicine, Facoltà di Medicina e Chirurgia, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy.
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MeSH Terms
Circadian Rhythm*
Hydrocortisone / blood
Insulin / blood
Leptin / blood*
Middle Aged
Obesity / classification,  physiopathology*
Time Factors
Reg. No./Substance:
0/Leptin; 11061-68-0/Insulin; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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