Document Detail

Circadian patterns in men acclimatized to intermittent hypoxia.
MedLine Citation:
PMID:  11403785     Owner:  NLM     Status:  MEDLINE    
Six men, normally working shifts of 7 days at high altitude (HA, 3800 m, approximately 480 mm Hg barometric pressure) followed by 7 days of rest at sea level (SL), were studied during the last days of their HA and SL shifts with a 24-h constant routine protocol of sustained wakefulness and minimal activity. The amplitude of the circadian oscillations of oxygen consumption, breathing rate, thoracic skin temperature and diastolic pressure did not differ between HA and SL. At HA, the amplitude of the tympanic and calf temperature oscillations, were, respectively, lower and higher than at SL. End-tidal P(CO2) and systolic pressure had larger amplitude oscillations at HA than at SL. Hence, also in humans, as previously shown in animals, hypoxia can affect some circadian patterns, including those involved in thermoregulation. These effects of hypoxia could contribute to sleep disturbances at HA and in patients with cardiorespiratory diseases.
M Vargas; D Jiménez; F León-Velarde; J Osorio; J P Mortola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  126     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-08-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  233-43     Citation Subset:  IM    
Centro de Investigación en Medicina de Altura, Mutual de Seguridad C. Ch. C., Iquique, Chile.
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MeSH Terms
Anoxia / physiopathology*
Blood Pressure / physiology
Carbon Dioxide
Circadian Rhythm*
Oxygen Consumption
Partial Pressure
Physical Exertion
Skin Temperature
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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