| Circadian pancreatic enzyme pattern and relationship between secretory and motor activity in fasting humans. | |
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MedLine Citation:
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PMID: 12133869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is unknown whether nonparallel pancreatic enzyme output occurs under basal conditions in humans. We aimed to determine whether the circadian or wake-sleep cycle influences the relationship among pancreatic enzymes or between pancreatic secretory and jejunal motor activity. Using orojejunal multilumen intubation, we measured enzyme outputs and proximal jejunal motility index during consecutive daytime and nighttime periods in each of seven fasting, healthy volunteers. Enzyme outputs were correlated tightly during daytime phases of wakefulness and nighttime phases of sleep (r > 0.72, P < 0.001). During nocturnal phases of wakefulness, output of proteases (r = 0.84, P < 0.001), but not of amylase and trypsin (r = 0.12), remained associated. Nocturnally, particularly during sleep, pancreatic secretory activity was directly correlated with jejunal motility index (r > 0.50, P < 0.001). In conclusion, parallel secretion of pancreatic enzymes dominates throughout the circadian cycle. Nonparallel secretion during nocturnal phases of wakefulness may be due to merely circadian effects or to the coupling of the wake-sleep and the circadian cycle. The association between fluctuations of secretory and motor activity appears to be particularly tight during the night. |
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Authors:
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Jutta Keller; Peter Layer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 93 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-22 Completed Date: 2003-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 592-600 Citation Subset: IM |
Affiliation:
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Department of Medicine, Israelitic Hospital, D-22297 Hamburg, Germany. keller@ik-h.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amylases / metabolism, secretion Chymotrypsin / metabolism, secretion Circadian Rhythm / physiology* Fasting / physiology* Gastrointestinal Motility / physiology* Humans Jejunum / physiology Pancreas / enzymology*, secretion* Sleep / physiology Trypsin / metabolism, secretion Wakefulness / physiology |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.-/Amylases; EC 3.4.21.1/Chymotrypsin; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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