| Circadian misalignment in mood disturbances. | |
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MedLine Citation:
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PMID: 19909668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent refinements in methodology allow chronobiological researchers to answer the following questions: is there circadian misalignment in sleep and mood disturbances, and, if so, is it of the phase-advance or phase-delay type? Measurement of the dim light melatonin onset-to-midsleep interval, or phase-angle difference, in sleep and mood disorders should answer these questions. Although the phase-advance hypothesis of affective disorders was formulated three decades ago, recent studies suggest that many, if not all, mood disturbances have a circadian misalignment component of the phase-delay type, operationally defined as a delay in the dim light melatonin onset relative to the sleep/wake cycle. Phase-delayed disorders can be treated with bright light in the morning and/or low-dose melatonin in the afternoon/evening. Phase-advanced disorders can be treated with bright light in the evening and/or low-dose melatonin in the morning. |
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Authors:
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Alfred J Lewy |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current psychiatry reports Volume: 11 ISSN: 1535-1645 ISO Abbreviation: Curr Psychiatry Rep Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888960 Medline TA: Curr Psychiatry Rep Country: United States |
Other Details:
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Languages: eng Pagination: 459-65 Citation Subset: IM |
Affiliation:
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Oregon Health & Science University, 3181 Southwest Sam Jackson Road, Portland, OR 97239, USA. lewy@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Circadian Rhythm* Humans Melatonin / therapeutic use Mood Disorders / therapy* Phototherapy* Sleep Time Factors |
| Chemical | |
Reg. No./Substance:
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73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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