Document Detail

Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease.
MedLine Citation:
PMID:  8532109     Owner:  NLM     Status:  MEDLINE    
Sleep-wake cycle disturbances suggest that circadian rhythms may be disrupted in patients with Alzheimer's disease (AD). In this study, we examined the circadian rhythms of core-body temperature and locomotor activity in 28 patients with probable AD and 10 healthy controls. AD patients had higher percent nocturnal activity than controls, corresponding to the clinical picture of fragmented sleep. The amplitude of the activity cycle in the AD patients was lower than that of controls and the acrophase of this cycle in AD patients was 4.5 h later. There was no difference in the amplitude of the core-body temperature circadian rhythm, but AD patients had delayed temperature acrophases. A subgroup of AD patients with large mean time differences between the acrophases of their activity and temperature cycles had lower temperature amplitudes and greater activity during the night. These findings suggest that a subgroup of AD patients with impaired endogenous pacemaker function may have a diminished capacity to synchronize the rhythm of core-body temperature with the circadian cycle of rest-activity. This circadian rhythm dysfunction may partly explain the fragmented nocturnal sleep exhibited by these patients.
A Satlin; L Volicer; E G Stopa; D Harper
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurobiology of aging     Volume:  16     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    1995 Sep-Oct
Date Detail:
Created Date:  1996-02-01     Completed Date:  1996-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  765-71     Citation Subset:  IM    
Department of Psychiatry, McLean Hospital, Belmont, MA 02178, USA.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / complications,  physiopathology*
Analysis of Variance
Biological Clocks
Body Temperature*
Circadian Rhythm*
Middle Aged
Motor Activity*
Sleep Disorders / etiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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