| Circadian gating of the cell cycle revealed in single cyanobacterial cells. | |
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MedLine Citation:
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PMID: 20299597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms. |
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Authors:
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Qiong Yang; Bernardo F Pando; Guogang Dong; Susan S Golden; Alexander van Oudenaarden |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 327 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-19 Completed Date: 2010-04-05 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1522-6 Citation Subset: IM |
Affiliation:
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Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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genetics,
metabolism Biological Clocks* Cell Cycle* Circadian Rhythm* Circadian Rhythm Signaling Peptides and Proteins / genetics, metabolism Computer Simulation Light Luminescent Proteins / metabolism Microscopy, Fluorescence Models, Biological Monte Carlo Method Synechococcus / cytology*, genetics, metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM062419-05A2/GM/NIGMS NIH HHS; R01 GM062419-06/GM/NIGMS NIH HHS; R01 GM062419-07/GM/NIGMS NIH HHS; R01 GM062419-10/GM/NIGMS NIH HHS; R01 GM068957-07/GM/NIGMS NIH HHS; R01 GM068957-08/GM/NIGMS NIH HHS; R01-GM062419/GM/NIGMS NIH HHS; R01-GM068957/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/Circadian Rhythm Signaling Peptides and Proteins; 0/KaiA protein, cyanobacteria; 0/KaiB protein, cyanobacteria; 0/KaiC protein, cyanobacteria; 0/Luminescent Proteins; 0/yellow fluorescent protein, Bacteria |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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